Barzilai University Medical Center

114 Research Day 2020 Barzilai University Medical Center 81 GLIOBLASTOMA MULTIFORME, DIAGNOSIS AND TREATMENT; RECENT LITERATURE REVIEW. Batash R 1 , Asna N 2 , Schaffer P 3 , Francis N 4 , Schaffer M 2 . 1 Department of Orthopedics, Barzilai University Medical Center, Ashkelon. Israel. 2 Department of Oncology, Barzilai University Medical Center, Ashkelon. Israel. 3 Department of Oncology, Bad Trissl Clinic, Oberaudorf. Germany. 4 Faculty of Medicine, Charles University, Prague, Czech Republic 5 Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. Background Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor prognosis showing a 5-year survival rate of 4-5%, and only a 26-33% survival rate at 2 years in clinical trials. Hypothesis Systemic compilation of the relevant literature. Objective In this paper, we review the different types of treatment modalities based on the relevant databases. Methods of diagnosis will be described briefly. Results Today's treatments cannot cure GBM patients but only extend their overall survival. The use of chemoradiation, immunotherapy, and radio sensitizers as an adjuvant therapy cannot reduce the high rates of recurrence within a few months after treatment. Conclusions Radiotherapy will remain the backbone of the treatment but new treatment modalities must be developed.