Barzilai University Medical Center

116 Research Day 2020 Barzilai University Medical Center 83 USE OF CEMIPLIMAB IN LOCALLY ADVANCED CUTANEOUS SQUAMOUS CELL CARCINOMA M. Schaffer 1,2* , I. Ostfeld 5 *, A. Simanovich 1,3 , R. Batash 3,7 , A. Livof ,3,4 , R. Talisman 3, 6 , N. Asna 1,3 1 Department of Oncology, Barzilai University Medical Center, Ashkelon, Israel 2 Department of Radiology, Barzilai University Medical Center, Ashkelon, Israel 3 Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel 4 Department of Pathology, Barzilai University Medical Center, Ashkelon, Israel 5 Israel National Social Security Agency, Jerusalem Israel 6 Department of Plastic Surgery, Barzilai University Medical Center, Ashkelon, Israel 7 Department of Orthopedics, Barzilai University Medical Center, Ashkelon, Israel. Background Cutaneous squamous cell carcinoma (cSCC), is one of the major types of skin cancer, along with basal cell cancer and melanoma. It usually presents as a hard lump with a scaly top but can also form as an ulcer. The greatest risk factor is high total exposure to ultraviolet radiation from the sun. Squamous cell carcinomas are generally treated by surgical excision, Mohs surgery or electrodessication and curettage. Non-surgical options for the treatment of cSCC include topical chemotherapy, topical immune response modifiers, photodynamic therapy (PDT), radiotherapy, and systemic chemotherapy. Hypothesis The suggested combination will reduce the tumor and achieve remission. Objectives To describe the outcomes of a combined cemiplimab (Libtayo) treatment with irradiation following resection of a cSCC in a 92 – year old patient. Results After 6 cycles of treatment, more than 50% tumor reduction (as shown by MRI) was seen, along with partial healing of wounds caused by bone destruction. Adverse effects appeared with a cutaneous rash, Grade IV, after the 5 th cycle, treated successfully with prednisone. Conclusions The use of Cemiplimab is safe and effective, and needs to be considered as a first-line treatment in such cases.