Barzilai University Medical Center

18 Research Day 2020 Barzilai University Medical Center 8 THE EFFECT OF CEREBRAL PALSY (CP) ON NEONATAL LINE THICKNESS AND ENAMEL COMPONENTS Fanny Hershkovitz, Shirley Leibovitz, Uri Zilberman Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. Background Cerebral Palsy (CP) is a disability in children characterized by a non-progressive motor disturbance of the central nervous system. It is a congenital disorder but it is not clear whether it is due to intrauterine developmental disorders or caused during birth. A neonatal line is an optical phenomenon caused by a change in the dimension, direction, and degree of calcification of the enamel prisms that is caused by biological stress in the sudden transition from intra-uterine to extra-uterine life. Objective Comparing the neonatal line width and the composition of the pre-natal and post-natal enamel in the deciduous teeth of children with cerebral palsy to the deciduous teeth of healthy children. Methods and materials 58 extracted or normally exfoliated deciduous teeth were collected for the study, 29 teeth from children with cerebral palsy and 29 pair matched teeth from healthy children who served as controls. The teeth were cut along the bucco-lingual/palatinal axis and examined using a light stereoscope and scanning electron microscope (SEM). The neonatal line was identified in 25 teeth and measured in width and the enamel concentrations of calcium, phosphorus, silicon, magnesium, sodium, oxygen, and carbon were measured in the pre-natal and post-natal enamel using ESD program. Results The neonatal line was significantly narrower in the deciduous teeth collected from children with cerebral palsy. In both groups, the concentration of magnesium and sodium in the pre-natal enamel was significantly higher than in the post-natal enamel. Magnesium and sodium levels were significantly higher in pre-natal enamel in the experimental group compared to the control group. Conclusions The neonatal line was narrower in the deciduous teeth collected from children with cerebral palsy than in those collected from healthy children. Children with cerebral palsy have a higher concentration of magnesium and sodium in the enamel that developed before birth.