Barzilai University Medical Center

61 Research Day 2020 Barzilai University Medical Center 41 PREGNANCY OUTCOMES IN WOMEN WITH UTERINE FIBROIDS Leonti Grin, Raz Berkovitz-Shperling, Sarit Mash-Reizer, Eyal Anteby, Efraim Zohav Department of Obstetrics and Gynecology, Barzilai University Medical Center Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel Background Uterine fibroids are common in reproductive age women. Previous reports showed an association between fibroids and adverse pregnancy and neonatal outcomes. Hypothesis The effect of fibroids on pregnancy complications is associated with the location, size and number of fibroids. Objectives The aim of this study was to explore the possible adverse obstetric outcomes in women with uterine fibroids according to number of fibroids their size and location. Results A retrospective analysis of maternal antenatal records and delivery records in all consecutive pregnant women attending Barzilai university hospital clinics was performed. Overall 133 pregnant women were eligible for the study group and matched with 330 controls. Baseline characteristics were similar between the study and control groups. In the study group, the average maximal fibroid diameter (mm) was 60±37. Adverse pregnancy outcomes in women with uterine fibroids versus normal uterus: preterm delivery (<37 weeks) OR 2.56, CI (1.426-4.56). Delivery by urgent cesarean section OR 2.18, CI (1.36-3.49). Sub analysis in women with a single versus multiple fibroids: preterm delivery (<37 weeks) OR 1.6, CI (0.6-4.26). Urgent cesarean delivery, OR 0.7, CI (0.28-1.748). In case of placenta on the same side as the fibroid: preterm delivery (<37 weeks) OR 1.09, CI (0.373-3.26). Urgent cesarean delivery, OR 0.82, CI (0.38-1.97). Other parameters were not significant predictors for adverse pregnancy outcomes Conclusions Pregnant women diagnosed with uterine fibroids might be at increased risk for adverse pregnancy outcome. Therefore, an early diagnosis of uterine fibroids could provide a reference to initiate a meticulous follow-up and counselling.