Barzilai University Medical Center

73 Research Day 2020 Barzilai University Medical Center 51 RISK FACTORS FOR DRY EYE AFTER REFRACTIVE SURGERY Kaiserman I 1 Shehadeh-Mashor R 2 , Mimouni M 3 , Shapira Y 3 1 Department of Ophthalmology, Barzilai University Medical Center, Ashkelon Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. 2 Department of Ophthalmology, The Baruch Padeh Medical Center, Poriya, Israel. 3 Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel. Background Dry eye is a common complication of refractive surgery. Hypothesis Various risk factors may affect the rate of dry eyes after refractive surgery Objectives To determine the factors associated with clinically significant dry eye after refractive surgery. Methods This is a large database retrospective study that included consecutive cases of myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy performed between 2008 and 2016 at Care- Vision Laser Center, Israel. Patients were divided into 2 groups according to whether they developed clinically significant dry eye. Results A total of 25,317 right eyes of 25,317 patients, with a mean age of 27.0 ± 8.3 years, were included. Postoperative dry eye developed in 1518 eyes (6.0%). The dry eye group was older (29.2 ± 9.0 vs. 27.6 ± 8.3 ys, P < 0.001) and had a higher proportion of women (48.5% vs. 44.8%, P = 0.005), lower preoperative spherical equivalent (3.7 ± 2.0 vs. 4.0 ± 2.3D, P < 0.001), lower preoperative best- corrected visual acuity (0.019 ± 0.057 vs. 0.016 ± 0.064 Logarithm of the Minimum Angle of Resolution (LogMAR), P = 0.04), and lower proportion of preoperative soft contact lens wearers (40.6% vs. 45.5%, P < 0.001). In the postoperative dry eye group, a high proportion underwent LASIK (52.4% vs. 38.7%, P < 0.001) and were treated with a 7.0-mm (as opposed to 6.0 mm) optic zone (18.9% vs. 16.3%, P < 0.001). In multivariable analysis, older age [odds ratio (OR) 1.013, P < 0.001], female gender (OR 0.87, P = 0.009), lower preoperative refractive error (OR 1.05, P < 0.001), and LASIK (OR 0.67, P < 0.001) were associated with postoperative dry eye. Conclusions Patients who are of older age, are of female gender, and have a lower preoperative refractive error and those undergoing LASIK are more likely to develop dry eye disease after refractive surgery.